Protein Details: ATP-sensitive inward rectifier potassium channel 15

Protein ID

ICDB_Pro_1361

Protein Name

ATP-sensitive inward rectifier potassium channel 15

Gene Name

Kcnj15

Organism

Rattus norvegicus (Rat)

Length

405 amino acids

AlphaFoldDB

AF-Q91ZF1-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity)

Sequence

MVARWVKGSEDAPLALQKIPDLQSGPRSLRMEAIHIGMSSAPLVKHSNGVGLKAHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVVYYAIAFIHGDLELGESNSNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVISKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQKLEEQYRQEDQRERELRSLLLQQSNV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1152/ajpgi.00256.2001

RefSeq

NP_579855.1 [Q91ZF1-1]; XP_006248190.1 [Q91ZF1-1]; XP_006248191.1 [Q91ZF1-1]; XP_006248193.1 [Q91ZF1-1]; XP_006248194.1 [Q91ZF1-1]; XP_006248195.1 [Q91ZF1-1]; XP_006248197.1 [Q91ZF1-1]; XP_006248201.1 [Q91ZF1-2]; XP_006248203.1 [Q91ZF1-2]; XP_008766772.1 [Q91ZF1-1]; XP_008766773.1; XP_008766774.1 [Q91ZF1-1]; XP_008766775.1; XP_017453350.1; XP_017453351.1 [Q91ZF1-1]; XP_017453352.1